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Consistently, administration of MIF to mice following ischemic stroke disrupted tight junctions of the BBB and increased infarct volumes in vivo , which could be reversed by a MIF antagonist (Liu et al., 2018)

Each one carries a specific instruction, telling cells what to do and when to do it

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Controlled human exposure studies have demonstrated that short-term exposure - up to 8 hours - causes lung function decrements such as reductions in forced expiratory volume in one second (FEV1), and the following respiratory symptoms: Cough Throat irritation Pain, burning, or discomfort in the chest when taking a deep breath Chest tightness, wheezing, or shortness of breath The effects are reversible, with improvement and recovery to baseline varying from a few hours to 48 hours after an elevated ozone exposure