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In particular: NICE Technology Appraisal TA875 provides a positive recommendation for semaglutide (Wegovy) for chronic weight management in adults meeting specific criteria (BMI 35 kg/m with at least one weight-related comorbidity, or BMI 3034.9 kg/m in certain circumstances), when used within a specialist weight management service

Important caveat: the idea that a GHRH analog plus a ghrelin agonist produce additive or synergistic GH output is a reasonable hypothesis, but it has not been validated for this specific blend or its dosing