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Hibbs JB Jr, Taintor RR, Vavrin Z, Rachlin EM

Figure 2 It has been hypothesized by certain researchers that there is an interaction between retinal macrophages and ferroptosis, given the resemblance in the functions of the macrophages and the traits of ferroptosis ( Macrophages phagocytosis contributes considerably to the removal of ferroptotic cells, which could release a DAMP called HMGB1 to activate and recruit macrophages, alerting immune defenses ( In the context of ferroptosis, either advanced glycosylation end-product specific receptor (AGER) or Toll-like receptors (TLR) on macrophages is required for DAMPs to mediate inflammation

The indoleamine structure of melatonin helps it exert antioxidant as well as anti-inflammatory effects in addition to acting on the SCN (the circadian master clock) to synchronize day-night rhythms

Coincidentally, the body's largest natural pulse of Growth Hormone also happens during the first few hours of deep sleep