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This pathway can control the expression of PEBP1, ERK1/2, GPX4, FTH1, ACSL4, and COX2, thereby enhancing the function of hippocampal astrocytes and microglial cells in CUMS model mice (Yang et al., 2023) (Table 1)

Table 1) These botanicals consist of various inorganic constituents and organic constituents including flavonoids, tannins, phenol, steroids, and protein) that have antioxidant, antidepressive, sedative, antianxiety and anti-inflammatory properties

In addition, aging may cause dysfunction of stem/progenitor cell renewal, rendering alveolar epithelial cells incapable of repairing and regenerating injured lungs