Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-Exatecan ligand Mukhopadhyay

Mukhopadhyay

856 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCN)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Science 2017

In a study using TMR-d12-SHTL

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-Exatecan ligand MukhopadhyaySOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I