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Clinical severity varies widely, depending on the degree to which the synthesis of the affected globin is impaired, altered synthesis of other globin chains, and coinheritance of other abnormal globin alleles

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192 Moreover, research in gastrointestinal cancer patients revealed upregulated serum ketone bodies, potentially driven by increased lipolysis and amino acid breakdown

RAPID RELIEF After only one intravenous (IV) infusion of STELARA , the majority of patients saw relief from their UC symptoms in just 8 weeks , with nearly 1 in 5 achieving remission.* LASTING REMISSION 4 out of 10 patients were in remission 1 year after responding to the IV induction dose and continuing treatment with STELARA