MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CAS

Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CAS Number 2736497-81-5  Related CAS Molecular Formula C17H20N2O4 Molecular Weight 316

Compared to tetramethylrhodamine maleimides and iodoacetamides

a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

Product Name: 5-TAMRA-PEG3-azide Synonyms: 5-Carboxytetramethylrhodamine-PEG3-Azide CAS Number: 1228100-59-1 Molecular Formula: C33H38N6O7 Molecular Weight: 630

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,