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The enhanced oral absorption may be attributed to reduced particle size, improved aqueous solubility, electrostatic mucoadhesion, and enhanced gastrointestinal retention [31]

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Thus, the results generated the hypothesis that chronic enhancement in the rate of active transport in AD (Ronquist and Waldenstrm, 2003) leading to the increase in ATP and 2,3-DPG hydrolysis and can increase in Hb affinity to oxygen, loss of adequate oxygen delivery to tissues that may be one of the factors contributing to brain hypoxia (Aliev et al., 2004), glucose hypometabolism, and memory dysfunction in AD

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