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Chemotherapy-induced peripheral neuropathy affects 30 to 40% of cancer patients receiving neurotoxic agents like taxanes, platinum compounds, and vinca alkaloids

Stahr PL, Grewal R, Eckert GP, Keck CM

However, increasing evidence supports a biphasic model in which moderate ROS levels facilitate adaptive signaling, whereas excessive ROS imposes cytotoxic stress and restricts tumor growth or metastasis [278,279,280]